The brain chemical serotonin—which is a neurotransmitter known for its function in transferring signals amid neurons in the brain—can also manage the expression of genes in neurons in an unanticipated way, as per to a study. This research was led by neuroscientists at the ISMMS (Icahn School of Medicine at Mount Sinai) and was published in the journal Nature. This discovery might assist researchers in a better understanding of a variety of brain diseases, counting substance abuse, addiction, mood disorders, and neurodegenerative disorders. Ian Maze—Assistant Professor at the ISMMS—said, “Our results represent a staged divergence from the present dogma, which functions primarily on the principle that neurotransmitters such as dopamine and serotonin act exclusively via the activation of their receptor membrane in the brain to direct brain cell activity.
Ian further added, “We discovered actions of the brain chemicals that are free of neurotransmission but very important to their in general signaling; recommending that our present understanding of these molecules is imperfect and needs further investigation.“ The study turns around DNA and how it functions to create each person’s unique biological map. Every cell in the body consists of 2 Meters of DNA, the design for all tasks of all cells in the body. This DNA is bound around coils of histone proteins—these are a type of proteins that package DNA in the cell’s nucleus and are greatly prone to chemical alterations that help in the regulation of gene expression—in the structures cited to as nucleosomes.
On a similar note, recently, a study showed that hyperactive brain cells might be blamed when antidepressants do not work. The commonly recommended antidepressants—SSRIs (selective serotonin reuptake inhibitors)—elevate the fog of depression for several people. But for people having a major depressive disorder, SSRIs do not make as such any difference. Scientists from the Salk Institute have stated down a potential reason why the neurons in some of these patients’ brains might develop into hyperactive in the incidence of the drugs. The study was published in Molecular Psychiatry.