Recently, a brand new study on the subject of side effects caused by antibiotic treatment has revealed that such treatment may affect skeletal development post puberty as they interfere with regular gut bacteria. The large number of bacteria residing within our bodies is extremely important for our body’s health as they contribute to regulating gastrointestinal systems as well as immune systems. Usually, bacteria are classified into ‘good’ and ‘bad’. The former causes no harm to our bodies while the latter are the reason for various diseases. These unwanted microbes are often treated using antibiotics.
Several researchers at South Carolina’s Medical University of in Charleston, have specialized in osteoimmunology. This is the study of interface of the immune systems and skeletal systems. These scientists have analyzed the effect of antibiotics on post-pubertal development of the skeletal system. The results were then published in The American Journal of Pathology.
The study illustrated that the disruption in gut microbiota caused by antibiotics leads to a type of pro-inflammatory reaction. This, in turn, leads to lower bone resorption, which is how osteoclasts, or in other words, large-sized bone cells, first release and then transfer the minerals to the blood. In the words of Chad M. Novince, Ph.D., this study has introduced antibiotics as an important exogenous modulator when it comes to gut microbiota and osteoimmune response in the process of post-pubertal development of the skeletal system.
A new study was conducted by Novince in order to determine how antibiotics impact the microbiota in the gut during skeletal development post puberty. The study saw mice being treated with a combination of 3 antibiotics and subsequent disruption of gut microbiota was noticed, along with noticeable changes in the trabecular bone, which is a spongy part extremely important for metabolism. In addition, the osteoclast cell count, along with their activity levels and size was elevated, thus affecting bone resorption.